P&TIT: A computer tool for predicting prototypical transcription promoter and terminator elements by conserved motifs

Abstract

Over the last few decades, computational genomics has tremendously contributed to decipher biology from genome sequences and related data. Considerable effort has been devoted to prediction of transcription promoter and terminator sites that represent the essential "punctuation marks" for DNA transcription. In this study we have investigated the possibility to identify putative promoters and Rho-dependent terminators in prokaryotes on the basis of evolutionarily conserved motifs. The final aim of this work is to develop computer software to predict location of bacterial promoters and terminators based on nucleic acid motifs.